NeuroSKILL’s Research

The NeuroSKILL Project is now CLOSED


Research

Manuscripts

Writing a manuscript for publication is a chance for researchers to be able to share their ideas with the public. The manuscript is used to communicate how the work was conducted and the results, enabling the audience to assess the veracity of the results and the conclusion.

These are the details of NeuroSKILL's manuscripts, currently being written.

Professor Arun Bokde (TCD) addresses the delegates at the UCC Study Day

Oral Presentations

Presentations are brief discussions of a focused topic delivered to a group of listeners in order to impart knowledge and to stimulate discussion. Oral presentations, beginning with an introduction and ending with a conclusion, are regarded as an excellent means of communicating basic science and clinical research.

These are NeuroSKILL's oral presentations.

Posters

Poster Presentations

The poster presentation is a dynamic communication tool, as a means to accommodate the increasing number of researchers, especially graduate students, seeking a means for scholarly presentations of their research.

These are NeuroSKILL's poster presentations.

TCD’s Current Research

Liz2We are conducting a research study using magnetic resonance imaging (MRI) in the Trinity College Institute of Neuroscience. The aim of the study is to investigate changes in the brain’s functional and structural networks in both healthy ageing and mild cognitive impairment (MCI).

We hope to relate these changes to performance on a number of cognitive and emotional tasks to better characterize the real-world implications of alterations in the brain’s connectivity. We are collecting data from three groups of participants; young adults aged between 18 and 30 years, older healthy adults aged between 55 and 80 years and older adults in the same age bracket but with mild memory problems.

The techniques we are using include functional MRI to measure the activity of the brain’s networks at rest; diffusion-weighted imaging to image the brain’s structural connections, the white matter tracts; and magnetic resonance spectroscopy (MRS) to measure brain chemistry. We hope that the findings from this study will increase our understanding of how ageing affects the brain’s networks, and may have the potential to be developed for use as biomarkers for the detection of early brain changes related to MCI and AD.

Dr Elizabeth Kehoe, July 2013

 

Bangor University’s Current Research

Paul MullinsThe team at Bangor University is investigating brain structural and chemical changes in healthy ageing and forms of dementia and memory loss like Korsakoff’s syndrome using MRI scanning.

During the MRI scanning the team investigated brain structure and white matter connectivity using diffusion tensor imaging (DTI). We are also investigating the neurochemistry of the ageing brain with magnetic resonance spectroscopy (MRS).

Lastly, the activity of the brain at rest, and the functional connectivity changes that occur with ageing and dementia will be studied using resting state functional magnetic resonance imaging (fMRI) techniques.

The data collected so far is currently being analysed for these purposes:

  • the structural scans are being used to investigate the volume of the hippocampus and its subfields, and the volume of grey and white matter;
  • DTI data, to study differences in white matter connectivity using both volumetric analysis and probabilistic tractography;
  • the fMRI data, to investigate the connectivity of the brain, and the dynamics of switching between differential network states; and
  • neurochemistry has been analysed to compare changes between healthy individuals and patients.

Combining all these measures and comparing to the work taking place in Trinity College Dublin will hopefully increase our understanding of the brain changes occurring in dementia, and how neuroimaging can play an important role in monitoring and researching this condition.

Dr Paul Mullins, December 2013